缓存标题：The New England Journal of Medicine | Research & Review Articles on Disease & Clinical Practice
缓存内容：Skip to main contentSUBSCRIBEOR RENEWSPECIALTIESTOPICSMULTIMEDIACURRENT ISSUELEARNING/CMEAUTHOR CENTERPUBLICATIONSSIGN IN|CREATE ACCOUNTSUBSCRIBESAVEORIGINAL ARTICLEAPR 08, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYTAVI or SAVR in Aortic-Valve StenosisS. Blankenberg and OthersA randomized trial that enrolled patients with severe aortic stenosis at low or intermediate surgical risk showed that TAVI was noninferior to SAVR at 1 year.Editorial Another Early Win for TAVI in Low-Risk PatientsORIGINAL ARTICLEAPR 07, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYBeta-Blockers after MI with Preserved Ejection FractionT. Yndigegn and OthersHospitalized patients with acute myocardial infarction and preserved EF were assigned to receive open-label long-term beta-blocker therapy or not. Beta-blockers did not lead to a lower risk of death or MI.Editorial Routine Beta-Blockers in Secondary Prevention — On Injured ReserveORIGINAL ARTICLEAPR 07, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYTAVR in Patients with a Small Aortic AnnulusH.C. Herrmann and OthersIn a trial of TAVR in patients with a small aortic annulus, a self-expanding valve was noninferior to a balloon-expandable valve for clinical outcomes and was superior for bioprosthetic-valve dysfunction through 12 months.ORIGINAL ARTICLEAPR 06, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYEmpagliflozin after Acute Myocardial InfarctionJ. Butler and OthersAmong patients hospitalized for acute myocardial infarction and at risk for heart failure, empagliflozin did not lead to a significantly lower risk of a first heart-failure hospitalization or death from any cause than placebo.Editorial Decreasing the Risk of Heart Failure in a Changing Post–Myocardial Infarction EnvironmentORIGINAL ARTICLEAPR 08, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYFFR-Guided Complete Revascularization for STEMIF. Böhm and OthersIn a registry-based trial, FFR-guided PCI of nonculprit lesions did not result in a lower risk of a composite of death from any cause, myocardial infarction, or unplanned revascularization than culprit-lesion-only PCI.Editorial Role of Physiology in the Management of Nonculprit Lesions in Acute Coronary SyndromeORIGINAL ARTICLEAPR 07, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYOlezarsen for HypertriglyceridemiaB.A. Bergmark and OthersIn a phase 2b trial involving patients with hypertriglyceridemia, the use of olezarsen (which targets APOC3 mRNA) for 6 months reduced triglyceride levels by approximately 50% as compared with placebo.Editorial Shooting the Messenger to Treat HypertriglyceridemiaORIGINAL ARTICLEAPR 07, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYOlezarsen for Familial Chylomicronemia SyndromeE.S. Stroes and OthersThe results of this phase 3 trial of the effect of olezarsen, a drug that targets APOC3 mRNA, on plasma triglyceride levels and acute pancreatitis in familial chylomicronemia syndrome support further clinical research.Editorial Shooting the Messenger to Treat HypertriglyceridemiaORIGINAL ARTICLEAPR 07, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYMicroaxial Flow Pump for STEMI and Cardiogenic ShockJ.E. Møller and OthersIn a randomized trial involving patients with STEMI and cardiogenic shock, mortality at 6 months was lower with mechanical circulatory support with a microaxial flow pump than with standard care alone.Editorial Mechanical Circulatory Support in Cardiogenic Shock — Persistence and ProgressORIGINAL ARTICLEAPR 06, 2024MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGYApoA1 and Outcomes after Myocardial InfarctionC.M. Gibson and OthersIn patients with acute MI, multivessel coronary artery disease, and other cardiovascular risk factors, CSL112 did not reduce the risk of MI, stroke, or death from cardiovascular causes.Editorial HDL Therapeutics — Time for a Curtain Call or Time to Reconceptualize?IMAGE CHALLENGEWhat is the diagnosis?ANSWEROriginal ResearchSAVEORIGINAL ARTICLECMEDissection in Breast Cancer with Sentinel-Node MetastasisJ. de Boniface and OthersPatients with sentinel-node metastasis at the time of breast-cancer surgery may undergo axillary dissection to remove more nodes, which can lead to side effects. In a trial, the additional surgery did not prolong survival.CORRESPONDENCESelpercatinib and Pseudo-Decreases in Kidney FunctionH. Izzedine, E. Bouderlique, and B. BesseSelpercatinib leads to pseudo-decreased kidney function, which impairs tubular creatinine excretion. Cystatin C has no tubular secretion and may be a better marker for managing selpercatinib treatment.ORIGINAL ARTICLECMETrial of Lixisenatide in Early Parkinson’s DiseaseW.G. Meissner and OthersIn a placebo-controlled trial involving persons with Parkinson’s disease, the subcutaneous GLP-1 receptor agonist lixisenatide was associated with reduced motor disability over a period of 12 months.ORIGINAL ARTICLEFREENirmatrelvir–Ritonavir in Outpatients with Covid-19J. Hammond and OthersIn fully vaccinated patients with risk factors for severe disease and patients (vaccinated or unvaccinated) without such risk factors, nirmatrelvir–ritonavir did not significantly shorten the time to alleviation of Covid-19 symptoms.ORIGINAL ARTICLEHospitalization for Chronic Kidney DiseaseM.A. Vazquez and OthersIn this trial involving patients with CKD, type 2 diabetes, and hypertension, the use of a personalized algorithm and practice facilitators in primary care clinics did not reduce hospitalization at 1 year.PHYSICIAN JOBSAPRIL 10, 2024New YorkNeonatal / Perinatal MedicineNeonatologist - Zucker School of Medicine at NorthwellPittsburgh, PennsylvaniaFamily MedicineFamily Medicine - PA and MDEureka, CaliforniaEmergency MedicineEmergency Medicine PhysicianSalem, MassachusettsPsychiatryChild Psychiatrist Opportunity - Near Boston, MANew YorkCardiologyHeart Failure, Pulmonary Hypertension Specialist needed in New York! - Northwell HealthIndianapolis, IndianaChiefs / Directors / Dept. HeadsVice Chair for Pediatric Education, Indiana University HealthClinical Practice and ReviewSAVECLINICAL DECISIONSAnticoagulation for Secondary Atrial FibrillationS. Li and OthersThis feature about a women with AF triggered by sepsis offers a case vignette accompanied by two essays, one supporting oral anticoagulant therapy after discharge and the other recommending no anticoagulant therapy. Cast your vote.PERSPECTIVEFREEPODCAST: NOT OTHERWISE SPECIFIEDBuilding Up without Breaking DownThis podcast episode asks how medical educators should navigate between demanding intense commitment and hard-won excellence from trainees and seriously threatening their well-being.PERSPECTIVEPODCAST: INTENTION TO TREATProgress for Parkinson’s?This podcast episode explores the fastest-growing neurologic condition in the world, Parkinson’s disease. What have we learned in recent years, and where are the greatest hopes for the future?REVIEW ARTICLECMEPreventing Cardiovascular Disease in Type 1 DiabetesC. Manrique-Acevedo, I.B. Hirsch, and R.H. EckelMore than half of newly diagnosed cases of type 1 diabetes occur in adulthood. This review focuses on the prevention of cardiovascular disease in patients with type 1 diabetes.CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITALCMEA Woman with Hyperglycemia Refractory to InsulinL.T. Fourman and OthersA 46-year-old woman with type 2 diabetes was admitted to this hospital because of hyperglycemia for which she was receiving over 2000 units of insulin per day. What is the diagnosis?PERSPECTIVEFREEDOUBLE TAKEWhat Is Rheumatoid Arthritis?G.S. Firestein and OthersThis Double Take video provides a review of the pathogenesis, clinical features, and diagnostic evaluation of rheumatoid arthritis as well as therapeutic approaches to the disease.Featured MultimediaSEE ALL MULTIMEDIAQUICK TAKEAPR 04, 2024Lixisenatide in Early Parkinson’s DiseaseQUICK TAKEAPR 04, 2024Hospitalization Rate in Chronic Kidney DiseaseQUICK TAKEAPR 04, 2024Nirmatrelvir for Covid-19 Outpatients高影响力医学文献及研究成果站在医学前沿，与权威医学信息相伴关注更多ARTICLE CATEGORIESResearchReviewsClinical CasesPerspectiveCommentaryOtherBrowse all ArticlesCurrent IssueIssue IndexRESOURCESAuthors & ReviewersSubmit a ManuscriptSubscribersInstitutional AdministratorsMediaAdvertisersAgentsPermissionsReprintsNEJM CareerCenterABOUT USAbout NEJMNEJM GroupProducts & ServicesEditors & PublishersAdvertising PoliciesContact UsAccessibilityFAQsHelpSite FeedbackSUBSCRIPTIONSSubscribeRenewActivate SubscriptionCreate AccountManage AccountPay BillInstitution SubscriptionsSpecial ContentSTAY CONNECTEDEmail AlertsCreate AccountAppsNEJM CareerCenterPodcastsRSS FeedRemote AccessFOLLOW USFacebookTwitterInstagramYoutubeLinkedInJOURNALS The New England Journal of Medicine NEJM Catalyst Innovations in Care Delivery NEJM Evidence NEJM AICopyright © 2024 Massachusetts Medical Society. 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