cryptography is a package designed to expose cryptographic primitives and recipes to Python developers. From 45.0.0 to before 46.0.7, if a non-contiguous buffer was passed to APIs which accepted Python buffers (e.g. Hash.update()), this could lead to buffer overflows. This vulnerability is fixed in 46.0.7.
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H